| Reaction Details |
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 | Report a problem with these data |
| Target | 72 kDa type IV collagenase |
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| Ligand | BDBM11548 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_334535 (CHEMBL862518) |
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| Ki | 3.8±n/a nM |
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| Citation |  Cherney, RJ; King, BW; Gilmore, JL; Liu, RQ; Covington, MB; Duan, JJ; Decicco, CP Conversion of potent MMP inhibitors into selective TACE inhibitors. Bioorg Med Chem Lett16:1028-31 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 72 kDa type IV collagenase |
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| Name: | 72 kDa type IV collagenase |
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| Synonyms: | 72 kDa gelatinase | 72 kDa type IV collagenase precursor | CLG4A | Gelatinase A | Gelatinase A (MMP-2) | MMP2 | MMP2_HUMAN | Matrix metalloproteinase-2 | Matrix metalloproteinase-2 (MMP 2) | Matrix metalloproteinase-2 (MMP2) | Matrix metalloproteinases 2 (MMP-2) | TBE-1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 73870.36 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08253 |
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| Residue: | 660 |
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| Sequence: | MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGC
PKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWD
KNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGD
GYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFN
GKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGT
SYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKY
ESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGAL
MAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQ
IRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEY
WIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDP
GFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC
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| BDBM11548 |
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| n/a |
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| Name | BDBM11548 |
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| Synonyms: | CHEMBL100570 | N-hydroxy-2-[(4-methoxy-1,1-biphenyl-4-yl)methyl]isothiazolidine-3-carboxamide 1,1-dioxide | N-hydroxy-2-{[4-(4-methoxyphenyl)phenyl]methyl}-1,1-dioxo-1,2-thiazolidine-3-carboxamide | Sultam Hydroxamate 15a |
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| Type | Small organic molecule |
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| Emp. Form. | C18H20N2O5S |
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| Mol. Mass. | 376.427 |
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| SMILES | COc1ccc(cc1)-c1ccc(CN2C(CCS2(=O)=O)C(=O)NO)cc1 |
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| Structure | 
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