Reaction Details |
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Target | Delta-type opioid receptor |
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Ligand | BDBM50177685 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_333515 (CHEMBL866454) |
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Ki | 710±n/a nM |
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Citation | Le Bourdonnec, B; Goodman, AJ; Michaut, M; Ye, HF; Graczyk, TM; Belanger, S; DeHaven, RN; Dolle, RE Synthesis and structure-activity relationships of a new series of 2alpha-substituted trans-4,5-dimethyl-4-(3-hydroxyphenyl)piperidine as mu-selective opioid antagonists. Bioorg Med Chem Lett16:864-8 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Delta-type opioid receptor |
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Name: | Delta-type opioid receptor |
Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40382.98 |
Organism: | Homo sapiens (Human) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
Residue: | 372 |
Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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BDBM50177685 |
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n/a |
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Name | BDBM50177685 |
Synonyms: | CHEMBL201845 | N-(2-(4-(3-hydroxyphenyl)-trans-4,5-dimethyl-1-phenethylpiperidin-2(alpha)-yl)ethyl)benzamide |
Type | Small organic molecule |
Emp. Form. | C30H36N2O2 |
Mol. Mass. | 456.619 |
SMILES | C[C@H]1CN(CCc2ccccc2)[C@H](CCNC(=O)c2ccccc2)C[C@@]1(C)c1cccc(O)c1 |
Structure |
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