| Reaction Details |
|---|
 | Report a problem with these data |
| Target | GTPase KRas |
|---|
| Ligand | BDBM50585384 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2231971 (CHEMBL5145743) |
|---|
| Kd | 36000±n/a nM |
|---|
| Citation |  Zheng, Q; Peacock, DM; Shokat, KM Drugging the Next Undruggable KRAS Allele-Gly12Asp. J Med Chem65:3119-3122 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| GTPase KRas |
|---|
| Name: | GTPase KRas |
|---|
| Synonyms: | GTPase KRas, N-terminally processed | K-Ras 2 | KRAS | KRAS2 | Ki-Ras | RASK2 | RASK_HUMAN | c-K-ras | c-Ki-ras |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 21656.10 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1476955 |
|---|
| Residue: | 189 |
|---|
| Sequence: | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIIM
|
|
|
|---|
| BDBM50585384 |
|---|
| n/a |
|---|
| Name | BDBM50585384 |
|---|
| Synonyms: | CHEMBL5084171 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H28ClFN6O |
|---|
| Mol. Mass. | 507.002 |
|---|
| SMILES | CN1CCC[C@H]1COc1nc(N2CCNCC2)c2cnc(c(F)c2n1)-c1cccc2cccc(Cl)c12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
