| Reaction Details |
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 | Report a problem with these data |
| Target | GTPase KRas |
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| Ligand | BDBM50579601 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2231977 (CHEMBL5145749) |
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| Kd | <0.000200±n/a nM |
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| Citation |  Zheng, Q; Peacock, DM; Shokat, KM Drugging the Next Undruggable KRAS Allele-Gly12Asp. J Med Chem65:3119-3122 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| GTPase KRas |
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| Name: | GTPase KRas |
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| Synonyms: | GTPase KRas, N-terminally processed | K-Ras 2 | KRAS | KRAS2 | Ki-Ras | RASK2 | RASK_HUMAN | c-K-ras | c-Ki-ras |
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| Type: | PROTEIN |
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| Mol. Mass.: | 21656.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1476955 |
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| Residue: | 189 |
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| Sequence: | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIIM
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|
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| BDBM50579601 |
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| n/a |
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| Name | BDBM50579601 |
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| Synonyms: | CHEMBL4858364 | US11453683, Example 252 | US20230279025, Example 481 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H31F3N6O2 |
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| Mol. Mass. | 600.6334 |
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| SMILES | Oc1cc(-c2ncc3c(nc(OC[C@@]45CCCN4C[C@H](F)C5)nc3c2F)N2CC3CCC(C2)N3)c2c(C#C)c(F)ccc2c1 |r| |
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| Structure | 
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