| Reaction Details |
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 | Report a problem with these data |
| Target | RuvB-like 1 |
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| Ligand | BDBM50600231 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2233418 (CHEMBL5147190) |
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| IC50 | 39000±n/a nM |
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| Citation |  Zhang, G; Wang, F; Li, S; Cheng, KW; Zhu, Y; Huo, R; Abdukirim, E; Kang, G; Chou, TF Discovery of small-molecule inhibitors of RUVBL1/2 ATPase. Bioorg Med Chem62:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| RuvB-like 1 |
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| Name: | RuvB-like 1 |
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| Synonyms: | 49 kDa TATA box-binding protein-interacting protein | 49 kDa TBP-interacting protein | 54 kDa erythrocyte cytosolic protein | ECP-54 | INO80 complex subunit H | INO80H | NMP 238 | NMP238 | Nuclear matrix protein 238 | Pontin 52 | RUVB1_HUMAN | RUVBL1 | TAP54-alpha | TIP49 | TIP49A | TIP60-associated protein 54-alpha |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50226.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_108308 |
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| Residue: | 456 |
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| Sequence: | MKIEEVKSTTKTQRIASHSHVKGLGLDESGLAKQAASGLVGQENAREACGVIVELIKSKK
MAGRAVLLAGPPGTGKTALALAIAQELGSKVPFCPMVGSEVYSTEIKKTEVLMENFRRAI
GLRIKETKEVYEGEVTELTPCETENPMGGYGKTISHVIIGLKTAKGTKQLKLDPSIFESL
QKERVEAGDVIYIEANSGAVKRQGRCDTYATEFDLEAEEYVPLPKGDVHKKKEIIQDVTL
HDLDVANARPQGGQDILSMMGQLMKPKKTEITDKLRGEINKVVNKYIDQGIAELVPGVLF
VDEVHMLDIECFTYLHRALESSIAPIVIFASNRGNCVIRGTEDITSPHGIPLDLLDRVMI
IRTMLYTPQEMKQIIKIRAQTEGINISEEALNHLGEIGTKTTLRYSVQLLTPANLLAKIN
GKDSIEKEHVEEISELFYDAKSSAKILADQQDKYMK
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| BDBM50600231 |
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| n/a |
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| Name | BDBM50600231 |
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| Synonyms: | CHEMBL5207433 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H32N8O3 |
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| Mol. Mass. | 540.6162 |
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| SMILES | COc1ccc(NC(=O)Nc2ccc(cc2)C2=NCCCN2)cc1NC(=O)Nc1ccc(cc1)C1=NCCCN1 |t:17,38| |
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| Structure | 
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