| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Melanocortin receptor 3 |
|---|
| Ligand | BDBM50179143 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_335085 (CHEMBL859202) |
|---|
| EC50 | 590±n/a nM |
|---|
| Citation |  Bakshi, RK; Hong, Q; Tang, R; Kalyani, RN; Macneil, T; Weinberg, DH; Van der Ploeg, LH; Patchett, AA; Nargund, RP Optimization of a privileged structure leading to potent and selective human melanocortin subtype-4 receptor ligands. Bioorg Med Chem Lett16:1130-3 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Melanocortin receptor 3 |
|---|
| Name: | Melanocortin receptor 3 |
|---|
| Synonyms: | MC3-R | MC3R | MC3R_HUMAN | Melanocortin MC3 | Melanocortin receptor (M3 and M4) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 36044.86 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P41968 |
|---|
| Residue: | 323 |
|---|
| Sequence: | MNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVI
LAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIF
DSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFI
VYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKG
AVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYA
FRSLELRNTFREILCGCNGMNLG
|
|
|
|---|
| BDBM50179143 |
|---|
| n/a |
|---|
| Name | BDBM50179143 |
|---|
| Synonyms: | (R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((N-isopropylmethan-2-ylsulfonamido)methyl)piperidin-1-yl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide | CHEMBL381125 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C35H49ClN4O4S |
|---|
| Mol. Mass. | 657.306 |
|---|
| SMILES | CC(C)N(CC1(CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H]1Cc2ccccc2CN1)C1CCCCC1)S(C)(=O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
