Reaction Details |
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Target | Thrombopoietin receptor |
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Ligand | BDBM50179474 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_338314 (CHEMBL866538) |
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EC50 | 4500±n/a nM |
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Citation | Safonov, IG; Heerding, DA; Keenan, RM; Price, AT; Erickson-Miller, CL; Hopson, CB; Levin, JL; Lord, KA; Tapley, PM New benzimidazoles as thrombopoietin receptor agonists. Bioorg Med Chem Lett16:1212-6 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Thrombopoietin receptor |
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Name: | Thrombopoietin receptor |
Synonyms: | C-mpl | CD_antigen=CD110 | MPL | Myeloproliferative leukemia protein | TPO-R | TPOR | TPOR_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 71243.48 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_535587 |
Residue: | 635 |
Sequence: | MPSWALFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPS
GTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNVFLNQTR
TQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNST
GPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGS
CLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTLDLKNVT
CQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDS
IIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQE
TCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQGPWSSWSDP
TRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLG
QYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLG
TMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP
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BDBM50179474 |
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n/a |
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Name | BDBM50179474 |
Synonyms: | 3-(2-(6-(4-tert-butylphenyl)pyridin-2-yl)-1H-benzo[d]imidazol-5-yl)-2-methylacrylic acid | CHEMBL426663 |
Type | Small organic molecule |
Emp. Form. | C26H25N3O2 |
Mol. Mass. | 411.4956 |
SMILES | CC(=Cc1ccc2nc([nH]c2c1)-c1cccc(n1)-c1ccc(cc1)C(C)(C)C)C(O)=O |w:2.2| |
Structure |
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