| Reaction Details |
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 | Report a problem with these data |
| Target | Thrombopoietin receptor |
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| Ligand | BDBM50179478 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_338314 (CHEMBL866538) |
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| EC50 | 1600±n/a nM |
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| Citation |  Safonov, IG; Heerding, DA; Keenan, RM; Price, AT; Erickson-Miller, CL; Hopson, CB; Levin, JL; Lord, KA; Tapley, PM New benzimidazoles as thrombopoietin receptor agonists. Bioorg Med Chem Lett16:1212-6 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thrombopoietin receptor |
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| Name: | Thrombopoietin receptor |
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| Synonyms: | C-mpl | CD_antigen=CD110 | MPL | Myeloproliferative leukemia protein | TPO-R | TPOR | TPOR_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 71243.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_535587 |
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| Residue: | 635 |
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| Sequence: | MPSWALFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPS
GTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNVFLNQTR
TQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNST
GPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGS
CLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTLDLKNVT
CQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDS
IIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQE
TCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQGPWSSWSDP
TRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLG
QYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLG
TMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP
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| BDBM50179478 |
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| n/a |
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| Name | BDBM50179478 |
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| Synonyms: | 5-((2-(6-(3,4-dimethylphenyl)pyridin-2-yl)-1H-benzo[d]imidazol-5-yl)methylene)-2-thioxothiazolidin-4-one | CHEMBL380407 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H18N4OS2 |
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| Mol. Mass. | 442.556 |
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| SMILES | Cc1ccc(cc1C)-c1cccc(n1)-c1nc2ccc(C=C3SC(S)=NC3=O)cc2[nH]1 |w:20.21,c:26| |
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| Structure | 
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