| Reaction Details |
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 | Report a problem with these data |
| Target | Parathyroid hormone/parathyroid hormone-related peptide receptor |
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| Ligand | BDBM50600473 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2234293 (CHEMBL5148065) |
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| IC50 | 280±n/a nM |
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| Citation |  Arai, Y; Kiyotsuka, Y; Nagamochi, M; Oyama, K; Izumi, M Lead optimization of pyrido[2,3-d][1]benzazepin-6-one derivatives leading to the discovery of a potent, selective, and orally available human parathyroid hormone receptor 1 (hPTHR1) antagonist (DS69910557). Bioorg Med Chem64:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Parathyroid hormone/parathyroid hormone-related peptide receptor |
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| Name: | Parathyroid hormone/parathyroid hormone-related peptide receptor |
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| Synonyms: | PTH/PTHr receptor | PTH/PTHrP type I receptor | PTH1 receptor | PTH1R | PTH1R_HUMAN | PTHR | PTHR1 | Parathyroid hormone 1 receptor | Parathyroid hormone receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 66370.95 |
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| Organism: | Homo sapiens (Human) |
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| Description: | PARATHYROID HT1 0 HUMAN::Q03431 |
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| Residue: | 593 |
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| Sequence: | MGTARIAPGLALLLCCPVLSSAYALVDADDVMTKEEQIFLLHRAQAQCEKRLKEVLQRPA
SIMESDKGWTSASTSGKPRKDKASGKLYPESEEDKEAPTGSRYRGRPCLPEWDHILCWPL
GAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVKFLTNETRE
REVFDRLGMIYTVGYSVSLASLTVAVLILAYFRRLHCTRNYIHMHLFLSFMLRAVSIFVK
DAVLYSGATLDEAERLTEEELRAIAQAPPPPATAAAGYAGCRVAVTFFLYFLATNYYWIL
VEGLYLHSLIFMAFFSEKKYLWGFTVFGWGLPAVFVAVWVSVRATLANTGCWDLSSGNKK
WIIQVPILASIVLNFILFINIVRVLATKLRETNAGRCDTRQQYRKLLKSTLVLMPLFGVH
YIVFMATPYTEVSGTLWQVQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIKKSWSRWTLA
LDFKRKARSGSSSYSYGPMVSHTSVTNVGPRVGLGLPLSPRLLPTATTNGHPQLPGHAKP
GTPALETLETTPPAMAAPKDDGFLNGSCSGLDEEASGPERPPALLQEEWETVM
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| BDBM50600473 |
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| n/a |
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| Name | BDBM50600473 |
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| Synonyms: | CHEMBL5183438 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H32Cl2N4O2 |
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| Mol. Mass. | 551.507 |
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| SMILES | CC1(C)c2ncc(Cl)cc2-c2ccc(Cl)cc2N(c2ccc(cc2)N2CC(CNC3CCOCC3)C2)C1=O |
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| Structure | 
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