| Reaction Details |
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 | Report a problem with these data |
| Target | Protein c-Fos/Transcription factor Jun |
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| Ligand | BDBM50180047 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_329857 (CHEMBL870579) |
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| IC50 | 5800±n/a nM |
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| Citation |  Tsuchida, K; Chaki, H; Takakura, T; Kotsubo, H; Tanaka, T; Aikawa, Y; Shiozawa, S; Hirono, S Discovery of nonpeptidic small-molecule AP-1 inhibitors: lead hopping based on a three-dimensional pharmacophore model. J Med Chem49:80-91 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein c-Fos/Transcription factor Jun |
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| Name: | Protein c-Fos/Transcription factor Jun |
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| Synonyms: | Proto-oncogene c-JUN/protein c-fos | Transcription factor AP1 |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of EBI is 305353 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Transcription factor Jun |
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| Synonyms: | AP1 | Activator protein 1 | JUN | JUN_HUMAN | Proto-oncogene c-JUN | Transcription factor AP-1 | Transcription factor AP1 | V-jun avian sarcoma virus 17 oncogene homolog | p39 |
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| Type: | n/a |
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| Mol. Mass.: | 35683.24 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P05412 |
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| Residue: | 331 |
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| Sequence: | MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDL
LTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAE
LHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGA
LSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETP
PLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANM
LREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
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| Component 2 |
| Name: | Protein c-Fos |
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| Synonyms: | FOS | FOS_HUMAN | G0S7 | Transcription factor AP1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 40679.34 |
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| Organism: | Homo sapiens (Human) |
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| Description: | EBI_100167 |
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| Residue: | 380 |
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| Sequence: | MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDFCTDLAVSSANF
IPTVTAISTSPDLQWLVQPALVSSVAPSQTRAPHPFGVPAPSAGAYSRAGVVKTMTGGRA
QSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQ
TEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSVASLDLTGGLPEVATPESEEAFT
LPLLNDPEPKPSVEPVKSISSMELKTEPFDDFLFPASSRPSGSETARSVPDMDLSGSFYA
ADWEPLHSGSLGMGPMATELEPLCTPVVTCTPSCTAYTSSFVFTYPEADSFPSCAAAHRK
GSSSNEPSSDSLSSPTLLAL
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| BDBM50180047 |
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| n/a |
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| Name | BDBM50180047 |
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| Synonyms: | 3-[2-isobutoxy-5-(3-isobutoxybenzoyl)phenyl]propionic acid | CHEMBL199325 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H30O5 |
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| Mol. Mass. | 398.492 |
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| SMILES | CC(C)COc1cccc(c1)C(=O)c1ccc(OCC(C)C)c(CCC(O)=O)c1 |
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| Structure | 
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