| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 2C |
|---|
| Ligand | BDBM50180251 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_329318 (CHEMBL863541) |
|---|
| EC50 | 3.7±n/a nM |
|---|
| Citation |  May, JA; Dantanarayana, AP; Zinke, PW; McLaughlin, MA; Sharif, NA 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. J Med Chem49:318-28 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 5-hydroxytryptamine receptor 2C |
|---|
| Name: | 5-hydroxytryptamine receptor 2C |
|---|
| Synonyms: | 5-HT2C | 5-hydroxytryptamine receptor 2C | 5-hydroxytryptamine receptor 2C (5HT2c) | 5HT2C_RAT | 5ht1c | Htr1c | Htr2c | Serotonin (5-HT) receptor | Serotonin receptor 2a and 2c (5HT2A and 5HT2C) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 51935.10 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | P08909 |
|---|
| Residue: | 460 |
|---|
| Sequence: | MVNLGNAVRSLLMHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALS
IVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYV
WPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVW
AISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIY
VLRRQTLMLLRGHTEEELANMSLNFLNCCCKKNGGEEENAPNPNPDQKPRRKKKEKRPRG
TMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGY
VCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIPRVAATALSGRELNVNIYRH
TNERVARKANDPEPGIEMQVENLELPVNPSNVVSERISSV
|
|
|
|---|
| BDBM50180251 |
|---|
| n/a |
|---|
| Name | BDBM50180251 |
|---|
| Synonyms: | 1-((S)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL371300 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H13N3O |
|---|
| Mol. Mass. | 191.2297 |
|---|
| SMILES | C[C@H](N)Cn1ncc2ccc(O)cc12 |
|---|
| Structure | 
|
|---|
Search and Browse
