| Reaction Details |
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 | Report a problem with these data |
| Target | 3-oxo-5-alpha-steroid 4-dehydrogenase 2 |
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| Ligand | BDBM50180898 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_327080 (CHEMBL859578) |
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| IC50 | 45±n/a nM |
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| Citation |  Salem, OI; Frotscher, M; Scherer, C; Neugebauer, A; Biemel, K; Streiber, M; Maas, R; Hartmann, RW Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids. J Med Chem49:748-59 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 3-oxo-5-alpha-steroid 4-dehydrogenase 2 |
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| Name: | 3-oxo-5-alpha-steroid 4-dehydrogenase 2 |
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| Synonyms: | 3-oxo-5-alpha-steroid 4-dehydrogenase 2 | 5 alpha-SR2 | 5α-Reductase 2 (5α-R2) | S5A2_HUMAN | SR type 2 | SRD5A2 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 2 | Type II 5-alpha reductase |
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| Type: | Enzyme |
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| Mol. Mass.: | 28406.59 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P31213 |
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| Residue: | 254 |
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| Sequence: | MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPS
FAVPAGILARQPLSLFGPPGTVLLGLFCLHYFHRTFVYSLLNRGRPYPAILILRGTAFCT
GNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRI
PQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFE
DYPKSRKALIPFIF
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| BDBM50180898 |
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| n/a |
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| Name | BDBM50180898 |
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| Synonyms: | (3-fluoro-4-(4-phenoxybenzoyl)phenyl)acetic acid | CHEMBL382214 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H15FO4 |
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| Mol. Mass. | 350.3398 |
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| SMILES | OC(=O)Cc1ccc(C(=O)c2ccc(Oc3ccccc3)cc2)c(F)c1 |
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| Structure | 
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