| Reaction Details |
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 | Report a problem with these data |
| Target | GTPase KRas |
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| Ligand | BDBM50601394 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2236233 (CHEMBL5150129) |
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| Kd | 190000±n/a nM |
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| Citation |  Korzeniecki, C; Priefer, R Targeting KRAS mutant cancers by preventing signaling transduction in the MAPK pathway. Eur J Med Chem211:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| GTPase KRas |
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| Name: | GTPase KRas |
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| Synonyms: | GTPase KRas, N-terminally processed | K-Ras 2 | KRAS | KRAS2 | Ki-Ras | RASK2 | RASK_HUMAN | c-K-ras | c-Ki-ras |
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| Type: | PROTEIN |
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| Mol. Mass.: | 21656.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1476955 |
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| Residue: | 189 |
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| Sequence: | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIIM
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| BDBM50601394 |
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| n/a |
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| Name | BDBM50601394 |
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| Synonyms: | CHEMBL5176776 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H27N5O |
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| Mol. Mass. | 377.4827 |
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| SMILES | CC[C@H](C)[C@H](N)C(=O)NC1=Cc2[nH]c(Cc3c[nH]c4ccccc34)nc2CC1 |r,t:9| |
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| Structure | 
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