| Reaction Details |
|---|
 | Report a problem with these data |
| Target | GTPase KRas |
|---|
| Ligand | BDBM50539763 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2236314 (CHEMBL5150210) |
|---|
| EC50 | 10.0±n/a nM |
|---|
| Citation |  Korzeniecki, C; Priefer, R Targeting KRAS mutant cancers by preventing signaling transduction in the MAPK pathway. Eur J Med Chem211:0 (2021) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| GTPase KRas |
|---|
| Name: | GTPase KRas |
|---|
| Synonyms: | GTPase KRas, N-terminally processed | K-Ras 2 | KRAS | KRAS2 | Ki-Ras | RASK2 | RASK_HUMAN | c-K-ras | c-Ki-ras |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 21656.10 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1476955 |
|---|
| Residue: | 189 |
|---|
| Sequence: | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIIM
|
|
|
|---|
| BDBM50539763 |
|---|
| n/a |
|---|
| Name | BDBM50539763 |
|---|
| Synonyms: | Adagrasib | Mrtx-849 | Mrtx849 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C32H35ClFN7O2 |
|---|
| Mol. Mass. | 604.117 |
|---|
| SMILES | CN1CCC[C@H]1COc1nc2CN(CCc2c(n1)N1CCN([C@@H](CC#N)C1)C(=O)C(F)=C)c1cccc2cccc(Cl)c12 |
|---|
| Structure | 
|
|---|
Search and Browse
