| Reaction Details |
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 | Report a problem with these data |
| Target | Squalene monooxygenase |
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| Ligand | BDBM18957 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_331288 (CHEMBL869978) |
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| IC50 | 12000±n/a nM |
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| Citation |  Benaim, G; Sanders, JM; Garcia-Marchán, Y; Colina, C; Lira, R; Caldera, AR; Payares, G; Sanoja, C; Burgos, JM; Leon-Rossell, A; Concepcion, JL; Schijman, AG; Levin, M; Oldfield, E; Urbina, JA Amiodarone has intrinsic anti-Trypanosoma cruzi activity and acts synergistically with posaconazole. J Med Chem49:892-9 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Squalene monooxygenase |
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| Name: | Squalene monooxygenase |
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| Synonyms: | ERG1 | ERG1_HUMAN | SE | SQLE | Squalene epoxidase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 63936.94 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_201924 |
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| Residue: | 574 |
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| Sequence: | MWTFLGIATFTYFYKKFGDFITLANREVLLCVLVFLSLGLVLSYRCRHRNGGLLGRQQSG
SQFALFSDILSGLPFIGFFWAKSPPESENKEQLEARRRRKGTNISETSLIGTAACTSTSS
QNDPEVIIVGAGVLGSALAAVLSRDGRKVTVIERDLKEPDRIVGEFLQPGGYHVLKDLGL
GDTVEGLDAQVVNGYMIHDQESKSEVQIPYPLSENNQVQSGRAFHHGRFIMSLRKAAMAE
PNAKFIEGVVLQLLEEDDVVMGVQYKDKETGDIKELHAPLTVVADGLFSKFRKSLVSNKV
SVSSHFVGFLMKNAPQFKANHAELILANPSPVLIYQISSSETRVLVDIRGEMPRNLREYM
VEKIYPQIPDHLKEPFLEATDNSHLRSMPASFLPPSSVKKRGVLLLGDAYNMRHPLTGGG
MTVAFKDIKLWRKLLKGIPDLYDDAAIFEAKKSFYWARKTSHSFVVNILAQALYELFSAT
DDSLHQLRKACFLYFKLGGECVAGPVGLLSVLSPNPLVLIGHFFAVAIYAVYFCFKSEPW
ITKPRALLSSGAVLYKACSVIFPLIYSEMKYMVH
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| BDBM18957 |
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| n/a |
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| Name | BDBM18957 |
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| Synonyms: | (2-{4-[(2-butyl-1-benzofuran-3-yl)carbonyl]-2,6-diiodophenoxy}ethyl)diethylamine | AMIODARONE HYDROCHLORIDE | Amiodarone | CHEMBL633 | Cordarone | L 3428 | cid_441325 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H29I2NO3 |
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| Mol. Mass. | 645.3116 |
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| SMILES | CCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCN(CC)CC)c(I)c1 |
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| Structure | 
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