| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Genome polyprotein |
|---|
| Ligand | BDBM50601687 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2237888 (CHEMBL5151784) |
|---|
| Kd | 9100±n/a nM |
|---|
| Citation |  Nascimento, IJDS; Santos-Júnior, PFDS; Aquino, TM; Araújo-Júnior, JX; Silva-Júnior, EFD Insights on Dengue and Zika NS5 RNA-dependent RNA polymerase (RdRp) inhibitors. Eur J Med Chem224:0 (2021) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Genome polyprotein |
|---|
| Name: | Genome polyprotein |
|---|
| Synonyms: | Nonstructural protein 5 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 102978.18 |
|---|
| Organism: | Dengue virus |
|---|
| Description: | ChEMBL_117874 |
|---|
| Residue: | 900 |
|---|
| Sequence: | GTGNTGETLGEKWKNRLNSLGKSEFQIYKRSGIQEVDRTLAKEGIKRGETDHHAVSRGSA
KLRWFVERNLVTPEGKVVDLGCGRGGWSYYCGGLKNVREVRGLTKGGPGHEEPIPMSTYG
WNLVRLQSGVDVFFTPPEKCDTLLCDIGESSPNPTVEAGRTLRVLNLVENWLNNNTQFCI
KVLNPYMPSVIEKMETLQRKYGGALVRNPLSRNSTHEMYWVSNASGNIVSSVNMISRMLI
NRFTMRHKKATYEPDVDLGSGTRNIGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPY
KTWAYHGSYETKQTGSASSVVNGVVRLLTKPWDVIPMVTQMAMTDTTPFGQQRVFKEKVD
TRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFARKVRSNAALGAIFTDENKWK
SAREAVEDSRFWELVDKERNLHLEGKCETCVYNMMGKREKKIGEFGKAKGSRAVWYMWLG
ARFLEFEALGFLNEDHWFSRENSLSGVEGEGLHKLGYILREVSKKEGGAMYADDTAGWDT
RITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRPTPRGTVMDIISRRDQRS
SGQVGTYGLNTFTNMGAQLIRQMEGEGVFKGIQHLTATEEVAVQDWLARVGRERLSRMAI
SGDDCVVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKD
GRVLVVPCRNQDELIGRARISQGAGWSLRETACLGKSYAQMWSLMYFHRRGLRLAANAIC
SAVPSHWVPTSRTTWSIHARHEWMTTEDMLTVWNRVWIQENPWMEDKTPVESWEEIPYLG
KRGDQWCGSLIGLTSRATWARNIQTAINRVRSLIGSEGYTDYMPSMKRFRREEDEAGVLW
|
|
|
|---|
| BDBM50601687 |
|---|
| n/a |
|---|
| Name | BDBM50601687 |
|---|
| Synonyms: | CHEMBL5192551 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H10ClFN4OS2 |
|---|
| Mol. Mass. | 416.88 |
|---|
| SMILES | Fc1cccc(\C=C2/S\C(NC2=O)=N\c2nnc(s2)-c2ccccc2Cl)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
