| Reaction Details |
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 | Report a problem with these data |
| Target | SAFB-like transcription modulator |
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| Ligand | BDBM50021574 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2238048 (CHEMBL5151944) |
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| IC50 | 1.3±n/a nM |
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| Citation |  Saha, D; Ryan, KR; Lakkaniga, NR; Acharya, B; Garcia, NG; Smith, EL; Frett, B Targeting Rearranged during Transfection in Cancer: A Perspective on Small-Molecule Inhibitors and Their Clinical Development. J Med Chem64:11747-11773 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| SAFB-like transcription modulator |
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| Name: | SAFB-like transcription modulator |
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| Synonyms: | MET | Modulator of estrogen-induced transcription | SLTM | SLTM_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 117162.12 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_119219 |
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| Residue: | 1034 |
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| Sequence: | MAAATGAVAASAASGQAEGKKITDLRVIDLKSELKRRNLDITGVKTVLISRLKQAIEEEG
GDPDNIELTVSTDTPNKKPTKGKGKKHEADELSGDASVEDDAFIKDCELENQEAHEQDGN
DELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKEDIESQEIEAQEGED
DTFLTAQDGEEEENEKDIAGSGDGTQEVSKPLPSEGSLAEADHTAHEEMEAHTTVKEAED
DNISVTIQAEDAITLDFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMN
ANHKDGKKEDCVKGDPVEKEARESSKKAESGDKEKDTLKKGPSSTGASGQAKSSSKESKD
SKTSSKDDKGSTSSTSGSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNAR
SPGAKCYGIVTMSSSTEVSRCIAHLHRTELHGQLISVEKVKGDPSKKEMKKENDEKSSSR
SSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQTSESI
KKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYR
RKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERERRERERIRIIREREERERL
QRERERLEIERQKLERERMERERLERERIRIEQERRKEAERIAREREELRRQQQQLRYEQ
EKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFP
ESSAVQSSSFERRDRFVGQSEGKKARPTARREDPSFERYPKNFSDSRRNEPPPPRNELRE
SDRREVRGERDERRTVIIHDRPDITHPRHPREAGPNPSRPTSWKSEGSMSTDKRETRVER
PERSGREVSGHSVRGAPPGNRSSASGYGSREGDRGVITDRGGGSQHYPEERHVVERHGRD
TSGPRKEWHGPPSQGPSYHDTRRMGDGRAGAGMITQHSSNASPINRIVQISGNSMPRGSG
SGFKPFKGGPPRRF
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| BDBM50021574 |
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| n/a |
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| Name | BDBM50021574 |
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| Synonyms: | BMS-907351 | CABOZANTINIB | CHEBI:72317 | Cabometyx | Cometriq | US10183928, Cabozantinib | US10202365, Compound Cabozantinib | US10227329, Compound Cabozantinib | US10273211, Compound Cabozantinib | US10464902, Cabozantinib | US10774070, Compound Cabozantinib | US11279688, Compound Cabozantinib | XL-184 | cabozantinib s-malate |
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| Type | Small organic molecule |
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| Emp. Form. | C28H24FN3O5 |
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| Mol. Mass. | 501.5057 |
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| SMILES | COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cc1OC |
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| Structure | 
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