| Reaction Details |
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 | Report a problem with these data |
| Target | Subtilisin-like protease 1 |
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| Ligand | BDBM50601907 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2238568 (CHEMBL5152464) |
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| IC50 | >50000±n/a nM |
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| Citation |  Lidumniece, E; Withers-Martinez, C; Hackett, F; Blackman, MJ; Jirgensons, A Subtilisin-like Serine Protease 1 (SUB1) as an Emerging Antimalarial Drug Target: Current Achievements in Inhibitor Discovery. J Med Chem65:12535-12545 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Subtilisin-like protease 1 |
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| Name: | Subtilisin-like protease 1 |
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| Synonyms: | SUB1 | SUB1_PLAFA | Subtilisin-like protease | Subtilisin-like serine protease | sub-1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 77866.88 |
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| Organism: | Plasmodium falciparum |
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| Description: | ChEMBL_830092 |
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| Residue: | 690 |
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| Sequence: | MMLNKKVVALCTLTLHLFCIFLCLGKEVRSEENGKIQDDAKKIVSELRFLEKVEDVIEKS
NIGGNEVDADENSFNPDTEVPIEEIEEIKMRELKDVKEEKNKNDNHNNNNNNNNISSSSS
SSSNTFGEEKEEVSKKKKKLRLIVSENHATTPSFFQESLLEPDVLSFLESKGNLSNLKNI
NSMIIELKEDTTDDELISYIKILEEKGALIESDKLVSADNIDISGIKDAIRRGEENIDVN
DYKSMLEVENDAEDYDKMFGMFNESHAATSKRKRHSTNERGYDTFSSPSYKTYSKSDYLY
DDDNNNNNYYYSHSSNGHNSSSRNSSSSRSRPGKYHFNDEFRNLQWGLDLSRLDETQELI
NEHQVMSTRICVIDSGIDYNHPDLKDNIELNLKELHGRKGFDDDNNGIVDDIYGANFVNN
SGNPMDDNYHGTHVSGIISAIGNNNIGVVGVDVNSKLIICKALDEHKLGRLGDMFKCLDY
CISRNAHMINGSFSFDEYSGIFNSSVEYLQRKGILFFVSASNCSHPKSSTPDIRKCDLSI
NAKYPPILSTVYDNVISVANLKKNDNNNHYSLSINSFYSNKYCQLAAPGTNIYSTAPHNS
YRKLNGTSMAAPHVAAIASLIFSINPDLSYKKVIQILKDSIVYLPSLKNMVAWAGYADIN
KAVNLAIKSKKTYINSNISNKWKKKSRYLH
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| BDBM50601907 |
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| n/a |
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| Name | BDBM50601907 |
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| Synonyms: | CHEMBL5199452 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H37F3N4O6 |
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| Mol. Mass. | 558.5904 |
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| SMILES | CC[C@H](C)[C@H](NC(C)=O)C(=O)N[C@@H]([C@@H](C)OCc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)C(F)(F)F |r| |
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| Structure | 
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