| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 3 |
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| Ligand | BDBM50601918 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2238591 (CHEMBL5152487) |
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| IC50 | 5.0±n/a nM |
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| Citation |  Fu, L; Chen, S; He, G; Chen, Y; Liu, B Targeting Extracellular Signal-Regulated Protein Kinase 1/2 (ERK1/2) in Cancer: An Update on Pharmacological Small-Molecule Inhibitors. J Med Chem65:13561-13573 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 3 |
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| Name: | Mitogen-activated protein kinase 3 |
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| Synonyms: | ERK1 | ERK1/ERK2 | Extracellular signal-regulated kinase 1 | Extracellular signal-regulated kinase 1 (ERK1) | MAP kinase ERK1 | MAPK3 | MAPK3/MAPK7 | MK03_HUMAN | Mitogen-activated protein kinase | Mitogen-activated protein kinase 3 | PRKM3 |
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| Type: | Protein |
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| Mol. Mass.: | 43136.58 |
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| Organism: | Homo sapiens (Human) |
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| Description: | curated by PDB 4QTB |
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| Residue: | 379 |
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| Sequence: | MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY
DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI
VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL
KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD
SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL
KELIFQETARFQPGVLEAP
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| BDBM50601918 |
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| n/a |
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| Name | BDBM50601918 |
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| Synonyms: | LY-3214996 | LY3214996 | Ly 3214996 | Ly3214996 | TEMUTERKIB | Temuterkib | [14c]-ly3214996 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H27N7O2S |
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| Mol. Mass. | 453.56 |
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| SMILES | Cn1nccc1Nc1nccc(n1)-c1cc2C(=O)N(CCN3CCOCC3)C(C)(C)c2s1 |
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| Structure | 
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