| Reaction Details |
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 | Report a problem with these data |
| Target | Perforin-1 |
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| Ligand | BDBM50235190 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2238679 (CHEMBL5152575) |
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| IC50 | 1170±n/a nM |
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| Citation |  Spicer, JA; Huttunen, KM; Jose, J; Dimitrov, I; Akhlaghi, H; Sutton, VR; Voskoboinik, I; Trapani, J Small Molecule Inhibitors of Lymphocyte Perforin as Focused Immunosuppressants for Infection and Autoimmunity. J Med Chem65:14305-14325 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Perforin-1 |
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| Name: | Perforin-1 |
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| Synonyms: | PERF_HUMAN | PFP | PRF1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 61392.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1285138 |
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| Residue: | 555 |
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| Sequence: | MAARLLLLGILLLLLPLPVPAPCHTAARSECKRSHKFVPGAWLAGEGVDVTSLRRSGSFP
VDTQRFLRPDGTCTLCENALQEGTLQRLPLALTNWRAQGSGCQRHVTRAKVSSTEAVARD
AARSIRNDWKVGLDVTPKPTSNVHVSVAGSHSQAANFAAQKTHQDQYSFSTDTVECRFYS
FHVVHTPPLHPDFKRALGDLPHHFNASTQPAYLRLISNYGTHFIRAVELGGRISALTALR
TCELALEGLTDNEVEDCLTVEAQVNIGIHGSISAEAKACEEKKKKHKMTASFHQTYRERH
SEVVGGHHTSINDLLFGIQAGPEQYSAWVNSLPGSPGLVDYTLEPLHVLLDSQDPRREAL
RRALSQYLTDRARWRDCSRPCPPGRQKSPRDPCQCVCHGSAVTTQDCCPRQRGLAQLEVT
FIQAWGLWGDWFTATDAYVKLFFGGQELRTSTVWDNNNPIWSVRLDFGDVLLATGGPLRL
QVWDQDSGRDDDLLGTCDQAPKSGSHEVRCNLNHGHLKFRYHARCLPHLGGGTCLDYVPQ
MLLGEPPGNRSGAVW
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| BDBM50235190 |
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| n/a |
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| Name | BDBM50235190 |
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| Synonyms: | CHEMBL4090472 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H17F2N3O3S2 |
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| Mol. Mass. | 497.537 |
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| SMILES | CN1Cc2cc(ccc2C1=O)-c1ccc(s1)-c1cncc(NS(=O)(=O)c2ccc(F)cc2F)c1 |
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| Structure | 
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