| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Ceramide glucosyltransferase |
|---|
| Ligand | BDBM50602025 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2238979 (CHEMBL5152875) |
|---|
| IC50 | 3.6±n/a nM |
|---|
| Citation |  Wang, J; Reynolds, M; Ibáñez, I; Sasaki, Y; Tanaka, Y; Kikuchi, F; Ohashi, T; Sato, S; Miyabayashi, M; Fujii, T; Tanaka, Y Photoredox-based late-stage functionalization in SAR study for in vivo potent glucosylceramide synthase inhibitor. Bioorg Med Chem Lett77:0 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Ceramide glucosyltransferase |
|---|
| Name: | Ceramide glucosyltransferase |
|---|
| Synonyms: | CEGT_HUMAN | GCS | GLCT-1 | Glucosylceramide synthase | UDP-glucose ceramide glucosyltransferase | UDP-glucose:N-acylsphingosine D-glucosyltransferase | UGCG |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 44859.25 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1435474 |
|---|
| Residue: | 394 |
|---|
| Sequence: | MALLDLALEGMAVFGFVLFLVLWLMHFMAIIYTRLHLNKKATDKQPYSKLPGVSLLKPLK
GVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVG
INPKINNLMPGYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGF
AATLEQVYFGTSHPRYYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMA
KAIADRGWRFAMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVAS
LIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMT
IYIFLSALWDPTISWRTGRYRLRCGGTAEEILDV
|
|
|
|---|
| BDBM50602025 |
|---|
| n/a |
|---|
| Name | BDBM50602025 |
|---|
| Synonyms: | CHEMBL5181454 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H27F3N2O4 |
|---|
| Mol. Mass. | 512.5202 |
|---|
| SMILES | CC(C)(O)c1ccc(cc1)N1Cc2c(cc(nc2-c2ccccc2OCC(F)(F)F)C2(C)COC2)C1=O |
|---|
| Structure | 
|
|---|
Search and Browse
