| Reaction Details |
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 | Report a problem with these data |
| Target | Polyunsaturated fatty acid lipoxygenase ALOX15 |
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| Ligand | BDBM50182513 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_332671 (CHEMBL858929) |
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| IC50 | >100000±n/a nM |
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| Citation |  Kenyon, V; Chorny, I; Carvajal, WJ; Holman, TR; Jacobson, MP Novel human lipoxygenase inhibitors discovered using virtual screening with homology models. J Med Chem49:1356-63 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polyunsaturated fatty acid lipoxygenase ALOX15 |
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| Name: | Polyunsaturated fatty acid lipoxygenase ALOX15 |
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| Synonyms: | 15-Lipoxygenase-1 (15-LOX-1) | ALOX15 | Arachidonate 15-lipoxygenase | Arachidonate 15-lipoxygenase-1 | LOG15 | LOX15_HUMAN | Reticulocyte 15-lipoxygenase-1 | Sphingosine 1-phosphate receptor 1 (S1P1) |
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| Type: | Protein |
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| Mol. Mass.: | 74804.05 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 662 |
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| Sequence: | MGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPL
LFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDP
QGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFLEDKRVDFEVSLAK
GLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVV
LRRSAHLPARLVFPPGMEELQAQLEKELEGGTLFEADFSLLDGIKANVILCSQQHLAAPL
VMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPMAWLLAKCWVRSSDFQLHELQSH
LLRGHLMAEVIVVATMRCLPSIHPIFKLIIPHLRYTLEINVRARTGLVSDMGIFDQIMST
GGGGHVQLLKQAGAFLTYSSFCPPDDLADRGLLGVKSSFYAQDALRLWEIIYRYVEGIVS
LHYKTDVAVKDDPELQTWCREITEIGLQGAQDRGFPVSLQARDQVCHFVTMCIFTCTGQH
ASVHLGQLDWYSWVPNAPCTMRLPPPTTKDATLETVMATLPNFHQASLQMSITWQLGRRQ
PVMVAVGQHEEEYFSGPEPKAVLKKFREELAALDKEIEIRNAKLDMPYEYLRPSVVENSV
AI
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| BDBM50182513 |
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| n/a |
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| Name | BDBM50182513 |
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| Synonyms: | CHEMBL204926 | ethyl 1-(3-(3,5-dimethylphenylamino)-3-oxopropyl)piperidine-4-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C19H28N2O3 |
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| Mol. Mass. | 332.4372 |
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| SMILES | CCOC(=O)C1CCN(CCC(=O)Nc2cc(C)cc(C)c2)CC1 |
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| Structure | 
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