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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Reverse transcriptase/RNaseH | ||
| Ligand | BDBM50183216 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_355438 (CHEMBL868998) | ||
| IC50 | 200±n/a nM | ||
| Citation |  Muraglia, E; Kinzel, OD; Laufer, R; Miller, MD; Moyer, G; Munshi, V; Orvieto, F; Palumbi, MC; Pescatore, G; Rowley, M; Williams, PD; Summa, V Tetrazole thioacetanilides: potent non-nucleoside inhibitors of WT HIV reverse transcriptase and its K103N mutant. Bioorg Med Chem Lett16:2748-52 (2006) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Reverse transcriptase/RNaseH | |||
| Name: | Reverse transcriptase/RNaseH | ||
| Synonyms: | HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 65229.15 | ||
| Organism: | Human immunodeficiency virus 1 | ||
| Description: | ChEMBL_1473730 | ||
| Residue: | 566 | ||
| Sequence: |
| ||
| BDBM50183216 | |||
| n/a | |||
| Name | BDBM50183216 | ||
| Synonyms: | 2-(1-mesityl-1H-tetrazol-5-ylthio)-N-(3-nitrophenyl)acetamide | CHEMBL381286 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H18N6O3S | ||
| Mol. Mass. | 398.439 | ||
| SMILES | Cc1cc(C)c(c(C)c1)-n1nnnc1SCC(=O)Nc1cccc(c1)[N+]([O-])=O |(14.54,-25.45,;14.88,-23.95,;13.74,-22.91,;14.07,-21.4,;12.94,-20.36,;15.54,-20.93,;16.68,-21.97,;18.14,-21.49,;16.35,-23.48,;15.86,-19.43,;14.84,-18.27,;15.61,-16.94,;17.12,-17.27,;17.27,-18.8,;18.6,-19.57,;19.94,-18.8,;21.27,-19.58,;21.27,-21.12,;22.6,-18.81,;23.94,-19.58,;23.93,-21.12,;25.26,-21.89,;26.6,-21.13,;26.59,-19.58,;25.26,-18.81,;27.94,-18.8,;29.27,-19.57,;27.93,-17.26,)| | ||
| Structure | 
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