| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 11 |
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| Ligand | BDBM50602546 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2241279 (CHEMBL5155489) |
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| IC50 | 6090±n/a nM |
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| Citation |  Dallavalle, S; Musso, L; Cincinelli, R; Darwiche, N; Gervasoni, S; Vistoli, G; Guglielmi, MB; La Porta, I; Pizzulo, M; Modica, E; Prosperi, F; Signorino, G; Colelli, F; Cardile, F; Fucci, A; D'Andrea, EL; Riccio, A; Pisano, C Antitumor activity of novel POLA1-HDAC11 dual inhibitors. Eur J Med Chem228:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 11 |
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| Name: | Histone deacetylase 11 |
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| Synonyms: | HD11 | HDA11_HUMAN | HDAC11 | Human HDAC11 |
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| Type: | Chromatin regulator; hydrolase; repressor |
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| Mol. Mass.: | 39187.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96DB2 |
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| Residue: | 347 |
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| Sequence: | MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSML
VEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG
TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL
DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER
NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT
SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
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| BDBM50602546 |
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| n/a |
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| Name | BDBM50602546 |
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| Synonyms: | CHEMBL5207505 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H29NO5 |
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| Mol. Mass. | 447.5229 |
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| SMILES | ONC(=O)COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc(C=CC(O)=O)cc1 |TLB:19:14:21:20.18.17,19:18:21:15.13.14,11:12:15:19.18.17,THB:20:18:15:21.13.12,20:12:15:19.18.17| |
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| Structure | 
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