| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone deacetylase 11 |
|---|
| Ligand | BDBM50602548 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2241279 (CHEMBL5155489) |
|---|
| IC50 | >10000±n/a nM |
|---|
| Citation |  Dallavalle, S; Musso, L; Cincinelli, R; Darwiche, N; Gervasoni, S; Vistoli, G; Guglielmi, MB; La Porta, I; Pizzulo, M; Modica, E; Prosperi, F; Signorino, G; Colelli, F; Cardile, F; Fucci, A; D'Andrea, EL; Riccio, A; Pisano, C Antitumor activity of novel POLA1-HDAC11 dual inhibitors. Eur J Med Chem228:0 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone deacetylase 11 |
|---|
| Name: | Histone deacetylase 11 |
|---|
| Synonyms: | HD11 | HDA11_HUMAN | HDAC11 | Human HDAC11 |
|---|
| Type: | Chromatin regulator; hydrolase; repressor |
|---|
| Mol. Mass.: | 39187.66 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q96DB2 |
|---|
| Residue: | 347 |
|---|
| Sequence: | MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSML
VEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG
TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL
DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER
NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT
SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
|
|
|
|---|
| BDBM50602548 |
|---|
| n/a |
|---|
| Name | BDBM50602548 |
|---|
| Synonyms: | CHEMBL5191222 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H26O3 |
|---|
| Mol. Mass. | 374.4721 |
|---|
| SMILES | OC(=O)C=Cc1ccc(cc1)-c1ccc(O)c(c1)C12CC3CC(CC(C3)C1)C2 |TLB:25:20:27:26.24.23,25:24:27:21.19.20,16:18:21:25.24.23,THB:26:24:21:27.19.18,26:18:21:25.24.23| |
|---|
| Structure | 
|
|---|
Search and Browse
