| Reaction Details |
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 | Report a problem with these data |
| Target | Stromelysin-1 |
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| Ligand | BDBM50183784 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_354052 (CHEMBL870697) |
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| Ki | 0.9±n/a nM |
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| Citation |  Janser, P; Neumann, U; Miltz, W; Feifel, R; Buhl, T A cassette-dosing approach for improvement of oral bioavailability of dual TACE/MMP inhibitors. Bioorg Med Chem Lett16:2632-6 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Stromelysin-1 |
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| Name: | Stromelysin-1 |
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| Synonyms: | MMP-3 | MMP3 | MMP3_HUMAN | Matrix metalloproteinase (2 and 3) | Matrix metalloproteinase 3 | Matrix metalloproteinase-3 | Matrix metalloproteinase-3 (MMP-3) | Matrix metalloproteinase-3 (MMP3) | SL-1 | STMY1 | Stromelysin 1 | Transin-1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 53973.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08254 |
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| Residue: | 477 |
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| Sequence: | MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPV
VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN
YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV
LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY
HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS
TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF
WAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEP
GFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
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| BDBM50183784 |
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| n/a |
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| Name | BDBM50183784 |
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| Synonyms: | (2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-N4-hydroxy-3-(hydroxymethyl)-2-(4-methoxyphenyl)succinamide | (2S,3R)-N4-((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-N1-hydroxy-2-hydroxymethyl-3-(4-methoxy-phenyl)-succinamide | CHEMBL72511 | N*4*-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-N*1*-hydroxy-2-hydroxymethyl-3-(4-methoxy-phenyl)-succinamide | PKF-242-484 | TNF-484 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H29N3O6 |
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| Mol. Mass. | 395.4501 |
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| SMILES | CNC(=O)[C@@H](NC(=O)[C@@H]([C@H](CO)C(=O)NO)c1ccc(OC)cc1)C(C)(C)C |r| |
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| Structure | 
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