| Reaction Details |
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 | Report a problem with these data |
| Target | Tau-tubulin kinase 2 |
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| Ligand | BDBM50602921 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2242610 (CHEMBL5156820) |
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| IC50 | 4490±n/a nM |
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| Citation |  Nozal, V; Martínez-González, L; Gomez-Almeria, M; Gonzalo-Consuegra, C; Santana, P; Chaikuad, A; Pérez-Cuevas, E; Knapp, S; Lietha, D; Ramírez, D; Petralla, S; Monti, B; Gil, C; Martín-Requero, A; Palomo, V; de Lago, E; Martinez, A TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy. J Med Chem65:1585-1607 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tau-tubulin kinase 2 |
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| Name: | Tau-tubulin kinase 2 |
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| Synonyms: | KIAA0847 | TTBK2 | TTBK2_HUMAN | Tau-tubulin kinase 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 137421.41 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_109480 |
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| Residue: | 1244 |
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| Sequence: | MSGGGEQLDILSVGILVKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQV
LKMEVAVLKKLQGKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLR
LGRQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVRPP
RAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDKEQVGSIKE
RYDHRLMLKHLPPEFSIFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDWEKT
GNDGSLTTTTTSTTPQLHTRLTPAAIGIANATPIPGDLLRENTDEVFPDEQLSDGENGIP
VGVSPDKLPGSLGHPRPQEKDVWEEMDANKNKIKLGICKAATEEENSHGQANGLLNAPSL
GSPIRVRSEITQPDRDIPLVRKLRSIHSFELEKRLTLEPKPDTDKFLETCLEKMQKDTSA
GKESILPALLHKPCVPAVSRTDHIWHYDEEYLPDASKPASANTPEQADGGGSNGFIAVNL
SSCKQEIDSKEWVIVDKEQDLQDFRTNEAVGHKTTGSPSDEEPEVLQVLEASPQDEKLQL
GPWAENDHLKKETSGVVLALSAEGPPTAASEQYTDRLELQPGAASQFIAATPTSLMEAQA
EGPLTAITIPRPSVASTQSTSGSFHCGQQPEKKDLQPMEPTVELYSPRENFSGLVVTEGE
PPSGGSRTDLGLQIDHIGHDMLPNIRESNKSQDLGPKELPDHNRLVVREFENLPGETEEK
SILLESDNEDEKLSRGQHCIEISSLPGDLVIVEKDHSATTEPLDVTKTQTFSVVPNQDKN
NEIMKLLTVGTSEISSRDIDPHVEGQIGQVAEMQKNKISKDDDIMSEDLPGHQGDLSTFL
HQEGKREKITPRNGELFHCVSENEHGAPTRKDMVRSSFVTRHSRIPVLAQEIDSTLESSS
PVSAKEKLLQKKAYQPDLVKLLVEKRQFKSFLGDLSSASDKLLEEKLATVPAPFCEEEVL
TPFSRLTVDSHLSRSAEDSFLSPIISQSRKSKIPRPVSWVNTDQVNSSTSSQFFPRPPPG
KPPTRPGVEARLRRYKVLGSSNSDSDLFSRLAQILQNGSQKPRSTTQCKSPGSPHNPKTP
PKSPVVPRRSPSASPRSSSLPRTSSSSPSRAGRPHHDQRSSSPHLGRSKSPPSHSGSSSS
RRSCQQEHCKPSKNGLKGSGSLHHHSASTKTPQGKSKPASKLSR
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| BDBM50602921 |
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| n/a |
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| Name | BDBM50602921 |
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| Synonyms: | CHEMBL5180098 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H14F3N5O |
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| Mol. Mass. | 385.3426 |
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| SMILES | Nc1nc(Nc2ccc(Oc3ccc(cc3)C(F)(F)F)cc2)c2cc[nH]c2n1 |
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| Structure | 
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