| Reaction Details |
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 | Report a problem with these data |
| Target | Chemerin-like receptor 1 |
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| Ligand | BDBM50603317 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2243619 (CHEMBL5157829) |
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| IC50 | 9.1±n/a nM |
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| Citation |  Imaizumi, T; Otsubo, S; Maemoto, M; Kobayashi, A; Komai, M; Takada, H; Sakaida, Y; Otsubo, N Discovery and mechanistic study of thiazole-4-acylsulfonamide derivatives as potent and orally active ChemR23 inhibitors with a long-acting effect in cynomolgus monkeys. Bioorg Med Chem56:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Chemerin-like receptor 1 |
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| Name: | Chemerin-like receptor 1 |
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| Synonyms: | CHEMR23 | CHEMR23 | CMKLR1 | CML1_HUMAN | Chemokine-like receptor 1 | DEZ | G-protein coupled receptor ChemR23 | G-protein coupled receptor DEZ |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42333.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_100822 |
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| Residue: | 373 |
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| Sequence: | MRMEDEDYNTSISYGDEYPDYLDSIVVLEDLSPLEARVTRIFLVVVYSIVCFLGILGNGL
VIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLI
HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDT
ANLHGKISCFNNFSLSTPGSSSWPTHSQMDPVGYSRHMVVTVTRFLCGFLVPVLIITACY
LTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYHTLNLLELHHTAMPGSVFSLGLPL
ATALAIANSCMNPILYVFMGQDFKKFKVALFSRLVNALSEDTGHSSYPSHRSFTKMSSMN
ERTSMNERETGML
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| BDBM50603317 |
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| n/a |
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| Name | BDBM50603317 |
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| Synonyms: | CHEMBL5204898 |
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| Type | Small organic molecule |
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| Emp. Form. | C64H78ClN9O12S2 |
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| Mol. Mass. | 1264.94 |
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| SMILES | CCNC(=O)CCC(=O)N1Cc2ccccc2-c2nnn(CCOCCOCCOCCOCCOCCOCCNC(=O)c3ccc(Cl)cc3-c3ccc(cc3)[C@@H](C)N(CC3CC3)c3nc(C(=O)NS(=O)(=O)C4CC4)c(s3)C3CC3)c2-c2ccccc12 |r| |
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| Structure | 
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