| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Chemerin-like receptor 1 |
|---|
| Ligand | BDBM50603318 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2243619 (CHEMBL5157829) |
|---|
| IC50 | 14±n/a nM |
|---|
| Citation |  Imaizumi, T; Otsubo, S; Maemoto, M; Kobayashi, A; Komai, M; Takada, H; Sakaida, Y; Otsubo, N Discovery and mechanistic study of thiazole-4-acylsulfonamide derivatives as potent and orally active ChemR23 inhibitors with a long-acting effect in cynomolgus monkeys. Bioorg Med Chem56:0 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Chemerin-like receptor 1 |
|---|
| Name: | Chemerin-like receptor 1 |
|---|
| Synonyms: | CHEMR23 | CHEMR23 | CMKLR1 | CML1_HUMAN | Chemokine-like receptor 1 | DEZ | G-protein coupled receptor ChemR23 | G-protein coupled receptor DEZ |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 42333.62 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_100822 |
|---|
| Residue: | 373 |
|---|
| Sequence: | MRMEDEDYNTSISYGDEYPDYLDSIVVLEDLSPLEARVTRIFLVVVYSIVCFLGILGNGL
VIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLI
HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDT
ANLHGKISCFNNFSLSTPGSSSWPTHSQMDPVGYSRHMVVTVTRFLCGFLVPVLIITACY
LTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYHTLNLLELHHTAMPGSVFSLGLPL
ATALAIANSCMNPILYVFMGQDFKKFKVALFSRLVNALSEDTGHSSYPSHRSFTKMSSMN
ERTSMNERETGML
|
|
|
|---|
| BDBM50603318 |
|---|
| n/a |
|---|
| Name | BDBM50603318 |
|---|
| Synonyms: | CHEMBL5183004 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C82H109ClN12O18S3 |
|---|
| Mol. Mass. | 1682.46 |
|---|
| SMILES | [H][C@]12CS[C@@H](CCCCC(=O)NCCOCCOCCOCCOCCC(=O)NCCC(=O)N3Cc4ccccc4-c4nnn(CCOCCOCCOCCOCCOCCOCCNC(=O)c5ccc(Cl)cc5-c5ccc(cc5)[C@@H](C)N(CC5CC5)c5nc(C(=O)NS(=O)(=O)C6CC6)c(s5)C5CC5)c4-c4ccccc34)[C@@]1([H])NC(=O)N2 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
