| Reaction Details |
|---|
 | Report a problem with these data |
| Target | D(1B) dopamine receptor |
|---|
| Ligand | BDBM50184440 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_337504 (CHEMBL861438) |
|---|
| Ki | 0.98±n/a nM |
|---|
| Citation |  Mohr, P; Decker, M; Enzensperger, C; Lehmann, J Dopamine/serotonin receptor ligands. 12(1): SAR studies on hexahydro-dibenz[d,g]azecines lead to 4-chloro-7-methyl-5,6,7,8,9,14-hexahydrodibenz[d,g]azecin-3-ol, the first picomolar D5-selective dopamine-receptor antagonist. J Med Chem49:2110-6 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| D(1B) dopamine receptor |
|---|
| Name: | D(1B) dopamine receptor |
|---|
| Synonyms: | D(5) dopamine receptor | D1beta dopamine receptor | DOPAMINE D5 | DRD1B | DRD1L2 | DRD5 | DRD5_HUMAN | dopamine receptor D5 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 52943.41 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P21918 |
|---|
| Residue: | 477 |
|---|
| Sequence: | MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVL
VCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFD
IMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNW
HRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAI
MIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAACAPDTSLRASIKKETKVLKTLSV
IMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYA
FNADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTP
GNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH
|
|
|
|---|
| BDBM50184440 |
|---|
| n/a |
|---|
| Name | BDBM50184440 |
|---|
| Synonyms: | 1-Chloro-2-hydroxy-7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecine | CHEMBL380464 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H20ClNO |
|---|
| Mol. Mass. | 301.811 |
|---|
| SMILES | CN1CCc2ccccc2Cc2c(CC1)ccc(O)c2Cl |
|---|
| Structure | 
|
|---|
Search and Browse
