Reaction Details |
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Target | Hypoxanthine-guanine phosphoribosyltransferase |
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Ligand | BDBM50603699 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2244965 (CHEMBL5159175) |
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Ki | 100±n/a nM |
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Citation | Klejch, T; Keough, DT; King, G; Dole?elová, E; ?esnek, M; Bud??ínský, M; Zíková, A; Janeba, Z; Guddat, LW; Hocková, D Stereo-Defined Acyclic Nucleoside Phosphonates are Selective and Potent Inhibitors of Parasite 6-Oxopurine Phosphoribosyltransferases. J Med Chem65:4030-4057 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Hypoxanthine-guanine phosphoribosyltransferase |
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Name: | Hypoxanthine-guanine phosphoribosyltransferase |
Synonyms: | HGPRT | HGPRTase | HPRT | HPRT1 | HPRT_HUMAN | Hypoxanthine-guanine phosphoribosyltransferase | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) |
Type: | Protein |
Mol. Mass.: | 24579.61 |
Organism: | Homo sapiens (Human) |
Description: | P00492 |
Residue: | 218 |
Sequence: | MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGH
HIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGD
DLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVG
FEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
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BDBM50603699 |
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n/a |
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Name | BDBM50603699 |
Synonyms: | CHEMBL5208021 |
Type | Small organic molecule |
Emp. Form. | C11H15N5Na4O10P2 |
Mol. Mass. | 531.1709 |
SMILES | n/a |
Structure |
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