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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Lysine-specific histone demethylase 2 | ||
| Ligand | BDBM50603907 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2245503 (CHEMBL5159713) | ||
| IC50 | 8890±n/a nM | ||
| Citation |  Li, C; Su, M; Zhu, W; Kan, W; Ge, T; Xu, G; Wang, S; Sheng, L; Gao, F; Ye, Y; Wang, J; Zhou, Y; Li, J; Liu, H Structure-Activity Relationship Study of Indolin-5-yl-cyclopropanamine Derivatives as Selective Lysine Specific Demethylase 1 (LSD1) Inhibitors. J Med Chem65:4335-4349 (2022) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Lysine-specific histone demethylase 2 | |||
| Name: | Lysine-specific histone demethylase 2 | ||
| Synonyms: | AOF1 | C6orf193 | Flavin-containing amine oxidase domain-containing protein 1 | KDM1B | KDM1B_HUMAN | LSD2 | Lysine-specific histone demethylase 1B | Lysine-specific histone demethylase 2 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 92112.91 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_992590 | ||
| Residue: | 822 | ||
| Sequence: |
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| BDBM50603907 | |||
| n/a | |||
| Name | BDBM50603907 | ||
| Synonyms: | CHEMBL5171190 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H29N3O2S | ||
| Mol. Mass. | 411.56 | ||
| SMILES | N[C@H]1CC[C@@H](CC1)NC1CC1c1ccc2N(CCc2c1)S(=O)(=O)c1ccccc1 |r,wU:4.7,wD:1.0,(9.26,4.43,;7.93,3.66,;6.59,4.43,;5.26,3.66,;5.26,2.12,;6.59,1.35,;7.93,2.12,;3.93,1.35,;2.59,2.12,;1.82,3.46,;1.05,2.12,;-.28,1.35,;-.28,-.18,;-1.61,-.95,;-2.94,-.19,;-4.4,-.66,;-5.31,.58,;-4.4,1.83,;-2.94,1.35,;-1.61,2.12,;-4.8,-2.15,;-4.4,-3.64,;-3.31,-2.55,;-6.29,-2.55,;-6.69,-4.04,;-8.17,-4.43,;-9.26,-3.34,;-8.87,-1.86,;-7.38,-1.46,)| | ||
| Structure | 
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