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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Lysine-specific histone demethylase 2 | ||
| Ligand | BDBM50603908 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2245503 (CHEMBL5159713) | ||
| IC50 | 1480±n/a nM | ||
| Citation |  Li, C; Su, M; Zhu, W; Kan, W; Ge, T; Xu, G; Wang, S; Sheng, L; Gao, F; Ye, Y; Wang, J; Zhou, Y; Li, J; Liu, H Structure-Activity Relationship Study of Indolin-5-yl-cyclopropanamine Derivatives as Selective Lysine Specific Demethylase 1 (LSD1) Inhibitors. J Med Chem65:4335-4349 (2022) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Lysine-specific histone demethylase 2 | |||
| Name: | Lysine-specific histone demethylase 2 | ||
| Synonyms: | AOF1 | C6orf193 | Flavin-containing amine oxidase domain-containing protein 1 | KDM1B | KDM1B_HUMAN | LSD2 | Lysine-specific histone demethylase 1B | Lysine-specific histone demethylase 2 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 92112.91 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_992590 | ||
| Residue: | 822 | ||
| Sequence: |
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| BDBM50603908 | |||
| n/a | |||
| Name | BDBM50603908 | ||
| Synonyms: | CHEMBL5177857 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H31N3O2S | ||
| Mol. Mass. | 425.587 | ||
| SMILES | N[C@H]1CC[C@H](CNC2CC2c2ccc3N(CCc3c2)S(=O)(=O)c2ccccc2)CC1 |r,wU:4.4,wD:1.0,(9.93,-.47,;8.59,.3,;8.59,1.84,;7.26,2.61,;5.93,1.84,;4.59,2.61,;3.26,1.84,;1.92,2.61,;1.15,3.94,;.38,2.61,;-.95,1.84,;-.95,.31,;-2.27,-.46,;-3.6,.3,;-5.07,-.18,;-5.97,1.07,;-5.07,2.32,;-3.6,1.84,;-2.28,2.61,;-5.47,-1.66,;-5.07,-3.15,;-3.98,-2.06,;-6.96,-2.06,;-7.35,-3.55,;-8.84,-3.94,;-9.93,-2.86,;-9.53,-1.37,;-8.05,-.97,;5.93,.3,;7.26,-.47,)| | ||
| Structure | 
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