| Reaction Details |
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 | Report a problem with these data |
| Target | Lysine-specific histone demethylase 2 |
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| Ligand | BDBM50603930 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2245503 (CHEMBL5159713) |
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| IC50 | 3950±n/a nM |
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| Citation |  Li, C; Su, M; Zhu, W; Kan, W; Ge, T; Xu, G; Wang, S; Sheng, L; Gao, F; Ye, Y; Wang, J; Zhou, Y; Li, J; Liu, H Structure-Activity Relationship Study of Indolin-5-yl-cyclopropanamine Derivatives as Selective Lysine Specific Demethylase 1 (LSD1) Inhibitors. J Med Chem65:4335-4349 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysine-specific histone demethylase 2 |
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| Name: | Lysine-specific histone demethylase 2 |
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| Synonyms: | AOF1 | C6orf193 | Flavin-containing amine oxidase domain-containing protein 1 | KDM1B | KDM1B_HUMAN | LSD2 | Lysine-specific histone demethylase 1B | Lysine-specific histone demethylase 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 92112.91 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_992590 |
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| Residue: | 822 |
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| Sequence: | MATPRGRTKKKASFDHSPDSLPLRSSGRQAKKKATETTDEDEDGGSEKKYRKCEKAGCTA
TCPVCFASASERCAKNGYTSRWYHLSCGEHFCNECFDHYYRSHKDGYDKYTTWKKIWTSN
GKTEPSPKAFMADQQLPYWVQCTKPECRKWRQLTKEIQLTPQIAKTYRCGMKPNTAIKPE
TSDHCSLPEDLRVLEVSNHWWYSMLILPPLLKDSVAAPLLSAYYPDCVGMSPSCTSTNRA
AATGNASPGKLEHSKAALSVHVPGMNRYFQPFYQPNECGKALCVRPDVMELDELYEFPEY
SRDPTMYLALRNLILALWYTNCKEALTPQKCIPHIIVRGLVRIRCVQEVERILYFMTRKG
LINTGVLSVGADQYLLPKDYHNKSVIIIGAGPAGLAAARQLHNFGIKVTVLEAKDRIGGR
VWDDKSFKGVTVGRGAQIVNGCINNPVALMCEQLGISMHKFGERCDLIQEGGRITDPTID
KRMDFHFNALLDVVSEWRKDKTQLQDVPLGEKIEEIYKAFIKESGIQFSELEGQVLQFHL
SNLEYACGSNLHQVSARSWDHNEFFAQFAGDHTLLTPGYSVIIEKLAEGLDIQLKSPVQC
IDYSGDEVQVTTTDGTGYSAQKVLVTVPLALLQKGAIQFNPPLSEKKMKAINSLGAGIIE
KIALQFPYRFWDSKVQGADFFGHVPPSASKRGLFAVFYDMDPQKKHSVLMSVIAGEAVAS
VRTLDDKQVLQQCMATLRELFKEQEVPDPTKYFVTRWSTDPWIQMAYSFVKTGGSGEAYD
IIAEDIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKIAAF
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| BDBM50603930 |
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| n/a |
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| Name | BDBM50603930 |
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| Synonyms: | CHEMBL5174650 | US11873292, Compound A54 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H31N3O |
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| Mol. Mass. | 341.4903 |
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| SMILES | CCCC(=O)N1CCc2cc(ccc12)C1CC1NCC1CCNCC1 |
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| Structure | 
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