Reaction Details |
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Target | 1-deoxy-D-xylulose 5-phosphate reductoisomerase |
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Ligand | BDBM50185361 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_344886 (CHEMBL870710) |
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IC50 | 50±n/a nM |
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Citation | Devreux, V; Wiesner, J; Goeman, JL; Van der Eycken, J; Jomaa, H; Van Calenbergh, S Synthesis and biological evaluation of cyclopropyl analogues of fosmidomycin as potent Plasmodium falciparum growth inhibitors. J Med Chem49:2656-60 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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1-deoxy-D-xylulose 5-phosphate reductoisomerase |
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Name: | 1-deoxy-D-xylulose 5-phosphate reductoisomerase |
Synonyms: | 1-Deoxy-D-xylulose 5-phosphate reductoisomerase (DXP) | 1-Deoxyxylulose 5-phosphate reductoisomerase (DXR) | 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) | 2-C-methyl-D-erythritol 4-phosphate synthase | DXP reductoisomerase | DXR_ECOLI | dxr | ispC | yaeM |
Type: | Protein |
Mol. Mass.: | 43384.52 |
Organism: | Escherichia coli |
Description: | P45568 |
Residue: | 398 |
Sequence: | MKQLTILGSTGSIGCSTLDVVRHNPEHFRVVALVAGKNVTRMVEQCLEFSPRYAVMDDEA
SAKLLKTMLQQQGSRTEVLSGQQAACDMAALEDVDQVMAAIVGAAGLLPTLAAIRAGKTI
LLANKESLVTCGRLFMDAVKQSKAQLLPVDSEHNAIFQSLPQPIQHNLGYADLEQNGVVS
ILLTGSGGPFRETPLRDLATMTPDQACRHPNWSMGRKISVDSATMMNKGLEYIEARWLFN
ASASQMEVLIHPQSVIHSMVRYQDGSVLAQLGEPDMRTPIAHTMAWPNRVNSGVKPLDFC
KLSALTFAAPDYDRYPCLKLAMEAFEQGQAATTALNAANEITVAAFLAQQIRFTDIAALN
LSVLEKMDMREPQCVDDVLSVDANAREVARKEVMRLAS
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BDBM50185361 |
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n/a |
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Name | BDBM50185361 |
Synonyms: | (1R,2S)-2-[N-(acetyl),N-(hydroxy)aminomethyl]-cyclopropylphosphonic acid | CHEMBL204406 |
Type | Small organic molecule |
Emp. Form. | C6H12NO5P |
Mol. Mass. | 209.1369 |
SMILES | CC(=O)N(O)C[C@@H]1C[C@H]1P(O)(O)=O |
Structure |
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