| Reaction Details |
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 | Report a problem with these data |
| Target | Adenylate cyclase type 8 |
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| Ligand | BDBM50604199 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2247167 (CHEMBL5161377) |
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| IC50 | 780±n/a nM |
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| Citation |  Scott, JA; Soto-Velasquez, M; Hayes, MP; LaVigne, JE; Miller, HR; Kaur, J; Ejendal, KFK; Watts, VJ; Flaherty, DP Optimization of a Pyrimidinone Series for Selective Inhibition of Ca J Med Chem65:4667-4686 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenylate cyclase type 8 |
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| Name: | Adenylate cyclase type 8 |
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| Synonyms: | 4.6.1.1 | AC8 | ADCY8 | ADCY8_HUMAN | ATP pyrophosphate-lyase 8 | Adenylate cyclase type 8 | Adenylate cyclase type VIII | Adenylyl cyclase 8 | Ca(2+)/calmodulin-activated adenylyl cyclase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 140131.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_104878 |
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| Residue: | 1251 |
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| Sequence: | MELSDVRCLTGSEELYTIHPTPPAGDGRSASRPQRLLWQTAVRHITEQRFIHGHRGGSGS
GSGGSGKASDPAGGGPNHHAPQLSGDSALPLYSLGPGERAHSTCGTKVFPERSGSGSASG
SGGGGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRK
SEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSHT
YLQYSGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLGTS
LLQVILQVVIPRLAVISINQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEAR
LRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADV
KGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAH
CCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKL
ESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEDSLLSLPED
IVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHV
QSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAF
IVLLFITAIQSLLPSSRVMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINE
TYLARNVIIFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTG
VLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLRYDNLNHSGEDFLGTKEV
SLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVA
RHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDE
LLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKH
SFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLIL
KDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLV
QSLNRQRQKQLLNENNNTGIIKGHYNRRTLLSPSGTEPGAQAEGTDKSDLP
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| BDBM50604199 |
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| n/a |
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| Name | BDBM50604199 |
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| Synonyms: | CHEMBL5178772 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H16FN5O2 |
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| Mol. Mass. | 341.3396 |
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| SMILES | CCc1cc(=O)[nH]c(n1)-n1nc(C)cc1NC(=O)c1ccc(F)cc1 |
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| Structure | 
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