| Reaction Details |
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 | Report a problem with these data |
| Target | Atrial natriuretic peptide receptor 3 |
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| Ligand | BDBM50604565 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2248267 (CHEMBL5162477) |
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| EC50 | 15510±n/a nM |
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| Citation |  Smith, RJ; Perez-Ternero, C; Conole, D; Martin, C; Myers, SH; Hobbs, AJ; Selwood, DL A Series of Substituted Bis-Aminotriazines Are Activators of the Natriuretic Peptide Receptor C. J Med Chem65:5495-5513 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Atrial natriuretic peptide receptor 3 |
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| Name: | Atrial natriuretic peptide receptor 3 |
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| Synonyms: | ANP-C | ANPR-C | ANPRC_RAT | Atrial natriuretic peptide clearance receptor | Atrial natriuretic peptide receptor type C | Npr-c | Npr3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59731.56 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_120672 |
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| Residue: | 535 |
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| Sequence: | MRSLLLFTFSACVLLARALLAGGASSGGGDTGPGNRRREREALAAQKIEVLVLLPRDDSY
LFSLARVRPAIEYALRSVEGNGTGRKLLPPGTRFQVAYEDSDCGNRALFSLVDRVAAARG
AKPDLILGPVCEYAAAPVARLASHWDLPMLSAGALAAGFQHKDTEYSHLTRVAPAYAKMG
EMMLALFRHHHWSRAALLYSDDKLERNCYFTLEGVHEVFQEEGLHTSAYNFDETKDLDLD
DIVRYIQGSERVVIMCASGDTIRRIMLAVHRHGMTSGDYAFFNIELFNSSSYGDGSWKRG
DKHDFEAKQAYSSLQTVTLLRTAKPEFEKFSMEVKSSVEKQGLNEEDYVNMFVEGFHDAI
LLYVLALHEVLRAGYSKKDGGKIIQQTWNRTFEGIAGQVSIDANGDRYGDFSVVAMTDTE
AGTQEVIGDYFGKEGRFKMRSNVKYPWGSLKLRIDETRIVEHTNSSPCKSCGLEESAVTG
IVVGALLGAGLLMAFYFFRKKYRITIERRNHQEESNIGKHRELREDSIRSHFSVA
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| BDBM50604565 |
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| n/a |
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| Name | BDBM50604565 |
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| Synonyms: | CHEMBL5180826 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H24N6O3 |
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| Mol. Mass. | 372.4216 |
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| SMILES | CC(=O)Nc1ccc(Nc2ncnc(NCCC(=O)OC(C)(C)C)n2)cc1 |
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| Structure | 
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