| Reaction Details |
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 | Report a problem with these data |
| Target | NACHT, LRR and PYD domains-containing protein 3 |
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| Ligand | BDBM50605051 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2250050 (CHEMBL5164260) |
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| IC50 | 0.230000±n/a nM |
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| Citation |  Narros-Fernández, P; Chioua, M; Petcu, SA; Diez-Iriepa, D; Cerrada-Gálvez, L; Decouty-Pérez, C; Palomino-Antolín, A; Ramos, E; Farré-Alins, V; López-Rodríguez, AB; Romero, A; Marco-Contelles, J; Egea, J Synthesis and Pharmacological Evaluation of New J Med Chem65:6250-6260 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NACHT, LRR and PYD domains-containing protein 3 |
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| Name: | NACHT, LRR and PYD domains-containing protein 3 |
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| Synonyms: | Cias1 | Cias1 | Cold autoinflammatory syndrome 1 protein homolog | Cryopyrin | Mast cell maturation-associated-inducible protein 1 | Mmig1 | NACHT, LRR and PYD domains-containing protein 3 | NLRP3_MOUSE | Nalp3 | Nlrp3 | PYRIN-containing APAF1-like protein 1 | Pypaf1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 118281.75 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_116758 |
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| Residue: | 1033 |
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| Sequence: | MTSVRCKLAQYLEDLEDVDLKKFKMHLEDYPPEKGCIPVPRGQMEKADHLDLATLMIDFN
GEEKAWAMAVWIFAAINRRDLWEKAKKDQPEWNDTCTSHSSMVCQEDSLEEEWMGLLGYL
SRISICKKKKDYCKMYRRHVRSRFYSIKDRNARLGESVDLNSRYTQLQLVKEHPSKQERE
HELLTIGRTKMRDSPMSSLKLELLFEPEDGHSEPVHTVVFQGAAGIGKTILARKIMLDWA
LGKLFKDKFDYLFFIHCREVSLRTPRSLADLIVSCWPDPNPPVCKILRKPSRILFLMDGF
DELQGAFDEHIGEVCTDWQKAVRGDILLSSLIRKKLLPKASLLITTRPVALEKLQHLLDH
PRHVEILGFSEAKRKEYFFKYFSNELQAREAFRLIQENEVLFTMCFIPLVCWIVCTGLKQ
QMETGKSLAQTSKTTTAVYVFFLSSLLQSRGGIEEHLFSDYLQGLCSLAADGIWNQKILF
EECDLRKHGLQKTDVSAFLRMNVFQKEVDCERFYSFSHMTFQEFFAAMYYLLEEEAEGET
VRKGPGGCSDLLNRDVKVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQ
QVRLELLKWIEVKAKAKKLQWQPSQLELFYCLYEMQEEDFVQSAMDHFPKIEINLSTRMD
HVVSSFCIKNCHRVKTLSLGFFHNSPKEEEEERRGGRPLDQVQCVFPDTHVACSSRLVNC
CLTSSFCRGLFSSLSTNRSLTELDLSDNTLGDPGMRVLCEALQHPGCNIQRLWLGRCGLS
HQCCFDISSVLSSSQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLQKLWLVSCCLTSAC
CQDLALVLSSNHSLTRLYIGENALGDSGVQVLCEKMKDPQCNLQKLGLVNSGLTSICCSA
LTSVLKTNQNFTHLYLRSNALGDTGLRLLCEGLLHPDCKLQMLELDNCSLTSHSCWNLST
ILTHNHSLRKLNLGNNDLGDLCVVTLCEVLKQQGCLLQSLQLGEMYLNRETKRALEALQE
EKPELTIVFEISW
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| BDBM50605051 |
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| n/a |
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| Name | BDBM50605051 |
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| Synonyms: | CHEMBL5184952 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H19N2NaO5S |
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| Mol. Mass. | 374.387 |
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| SMILES | [Na;v0+].[#6]-c1cc(-[#6])cc(-[#7]-[#6](=O)-[#7-]S(=O)(=O)c2cc(co2)C([#6])([#6])[#8])c1 |
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| Structure | 
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