| Reaction Details |
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 | Report a problem with these data |
| Target | Melanocortin receptor 4 |
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| Ligand | BDBM50186879 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_376465 (CHEMBL863666) |
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| Ki | 170±n/a nM |
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| Citation |  Tran, JA; Pontillo, J; Fleck, BA; Marinkovic, D; Arellano, M; Tucci, FC; Lanier, M; Saunders, J; Jiang, W; Chen, CW; Foster, AC; Chen, C Design, synthesis, and SAR studies on a series of 2-pyridinylpiperazines as potent antagonists of the melanocortin-4 receptor. Bioorg Med Chem Lett16:3693-6 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanocortin receptor 4 |
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| Name: | Melanocortin receptor 4 |
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| Synonyms: | MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R) |
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| Type: | Enzyme |
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| Mol. Mass.: | 36949.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P32245 |
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| Residue: | 332 |
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| Sequence: | MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
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| BDBM50186879 |
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| n/a |
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| Name | BDBM50186879 |
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| Synonyms: | (R)-3-amino-N-(3-(2,4-dichlorophenyl)-1-oxo-1-(4-(3-((2,2,2-trifluoroethylamino)methyl)pyridin-2-yl)piperazin-1-yl)propan-2-yl)propanamide | CHEMBL212358 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H29Cl2F3N6O2 |
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| Mol. Mass. | 561.427 |
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| SMILES | NCCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ncccc1CNCC(F)(F)F |
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| Structure | 
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