| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1 |
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| Ligand | BDBM50187090 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_383318 (CHEMBL867344) |
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| IC50 | 2000±n/a nM |
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| Citation |  Moradei, O; Leit, S; Zhou, N; Fréchette, S; Paquin, I; Raeppel, S; Gaudette, F; Bouchain, G; Woo, SH; Vaisburg, A; Fournel, M; Kalita, A; Lu, A; Trachy-Bourget, MC; Yan, PT; Liu, J; Li, Z; Rahil, J; MacLeod, AR; Besterman, JM; Delorme, D Substituted N-(2-aminophenyl)-benzamides, (E)-N-(2-aminophenyl)-acrylamides and their analogues: novel classes of histone deacetylase inhibitors. Bioorg Med Chem Lett16:4048-52 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 1 |
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| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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| BDBM50187090 |
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| n/a |
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| Name | BDBM50187090 |
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| Synonyms: | 3-(6-(4-(trifluoromethoxy)benzylamino)pyridin-3-yl)-N-(2-aminophenyl)acrylamide | CHEMBL425432 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H19F3N4O2 |
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| Mol. Mass. | 428.4071 |
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| SMILES | Nc1ccccc1NC(=O)\C=C\c1ccc(NCc2ccc(OC(F)(F)F)cc2)nc1 |
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| Structure | 
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