| Reaction Details |
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 | Report a problem with these data |
| Target | WD repeat-containing protein 5 |
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| Ligand | BDBM50605324 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2250997 (CHEMBL5165207) |
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| Ki | 0.029000±n/a nM |
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| Citation |  Teuscher, KB; Meyers, KM; Wei, Q; Mills, JJ; Tian, J; Alvarado, J; Sai, J; Van Meveren, M; South, TM; Rietz, TA; Zhao, B; Moore, WJ; Stott, GM; Tansey, WP; Lee, T; Fesik, SW Discovery of Potent Orally Bioavailable WD Repeat Domain 5 (WDR5) Inhibitors Using a Pharmacophore-Based Optimization. J Med Chem65:6287-6312 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| WD repeat-containing protein 5 |
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| Name: | WD repeat-containing protein 5 |
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| Synonyms: | BIG3 | WD repeat-containing protein 5 | WD repeat-containing protein 5 (WDR5) | WD repeat-containing protein 5 (WRD5) | WDR5 | WDR5_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 36597.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P61964 |
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| Residue: | 334 |
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| Sequence: | MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL
ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK
CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN
RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL
WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH
TDVVISTACHPTENIIASAALENDKTIKLWKSDC
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| BDBM50605324 |
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| n/a |
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| Name | BDBM50605324 |
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| Synonyms: | CHEMBL5182982 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H31N5O3 |
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| Mol. Mass. | 497.5881 |
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| SMILES | COc1cc(CN2CCc3c(cc(Cn4ccn(C)c4=N)cc3-c3ccncc3C)C2=O)cc(OC)c1 |
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| Structure | 
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