| Reaction Details |
|---|
 | Report a problem with these data |
| Target | WD repeat-containing protein 5 |
|---|
| Ligand | BDBM50605349 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2250997 (CHEMBL5165207) |
|---|
| Ki | <0.020000±n/a nM |
|---|
| Citation |  Teuscher, KB; Meyers, KM; Wei, Q; Mills, JJ; Tian, J; Alvarado, J; Sai, J; Van Meveren, M; South, TM; Rietz, TA; Zhao, B; Moore, WJ; Stott, GM; Tansey, WP; Lee, T; Fesik, SW Discovery of Potent Orally Bioavailable WD Repeat Domain 5 (WDR5) Inhibitors Using a Pharmacophore-Based Optimization. J Med Chem65:6287-6312 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| WD repeat-containing protein 5 |
|---|
| Name: | WD repeat-containing protein 5 |
|---|
| Synonyms: | BIG3 | WD repeat-containing protein 5 | WD repeat-containing protein 5 (WDR5) | WD repeat-containing protein 5 (WRD5) | WDR5 | WDR5_HUMAN |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 36597.13 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P61964 |
|---|
| Residue: | 334 |
|---|
| Sequence: | MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL
ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK
CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN
RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL
WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH
TDVVISTACHPTENIIASAALENDKTIKLWKSDC
|
|
|
|---|
| BDBM50605349 |
|---|
| n/a |
|---|
| Name | BDBM50605349 |
|---|
| Synonyms: | CHEMBL5191181 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H29F3N6O |
|---|
| Mol. Mass. | 522.5647 |
|---|
| SMILES | CCc1ccnc(CN2CCc3c(cc(Cn4ccnc4C)cc3C2=O)-c2cn(CC)nc2C(F)(F)F)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
