Reaction Details |
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Target | Calcium/calmodulin-dependent protein kinase type II subunit alpha |
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Ligand | BDBM50605607 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2252268 (CHEMBL5166478) |
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Ki | 77±n/a nM |
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Citation | Tian, Y; Shehata, MA; Gauger, SJ; Ng, CKL; Solbak, S; Thiesen, L; Bruus-Jensen, J; Krall, J; Bundgaard, C; Gibson, KM; Wellendorph, P; Frĝlund, B Discovery and Optimization of 5-Hydroxy-Diclofenac toward a New Class of Ligands with Nanomolar Affinity for the CaMKII? Hub Domain. J Med Chem65:6656-6676 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Calcium/calmodulin-dependent protein kinase type II subunit alpha |
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Name: | Calcium/calmodulin-dependent protein kinase type II subunit alpha |
Synonyms: | CaM Kinase II | Calcium/calmodulin-dependent protein kinase type II, rat brain | Camk2a | KCC2A_RAT | calcium/calmodulin-dependent protein kinase II alpha subunit |
Type: | Enzyme Mixture |
Mol. Mass.: | 54120.65 |
Organism: | Rattus norvegicus (rat) |
Description: | Consists of subunits of M.W. 50,000 and 58,000-60,000
in a 3:1 ratio. |
Residue: | 478 |
Sequence: | MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLERE
ARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQIL
EAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYL
SPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTV
TPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLK
GAILTTMLATRNFSGGKSGGNKKNDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEA
ISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIH
LMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH
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BDBM50605607 |
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n/a |
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Name | BDBM50605607 |
Synonyms: | CHEMBL5181512 |
Type | Small organic molecule |
Emp. Form. | C14H12O3S |
Mol. Mass. | 260.308 |
SMILES | OC(=O)Cc1ccc(O)cc1Sc1ccccc1 |
Structure |
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