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TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha
LigandBDBM16426
Substrate/Competitorn/a
Meas. Tech.ChEMBL_2252301 (CHEMBL5166511)
IC50 2.1±n/a nM
Citation Tian, Y; Shehata, MA; Gauger, SJ; Ng, CKL; Solbak, S; Thiesen, L; Bruus-Jensen, J; Krall, J; Bundgaard, C; Gibson, KM; Wellendorph, P; Frĝlund, B Discovery and Optimization of 5-Hydroxy-Diclofenac toward a New Class of Ligands with Nanomolar Affinity for the CaMKII? Hub Domain. J Med Chem65:6656-6676 (2022) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Calcium/calmodulin-dependent protein kinase type II subunit alpha
Name:Calcium/calmodulin-dependent protein kinase type II subunit alpha
Synonyms:CaM Kinase II | Calcium/calmodulin-dependent protein kinase type II, rat brain | Camk2a | KCC2A_RAT | calcium/calmodulin-dependent protein kinase II alpha subunit
Type:Enzyme Mixture
Mol. Mass.:54120.65
Organism:Rattus norvegicus (rat)
Description:Consists of subunits of M.W. 50,000 and 58,000-60,000 in a 3:1 ratio.
Residue:478
Sequence:
MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLERE
ARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQIL
EAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYL
SPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTV
TPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLK
GAILTTMLATRNFSGGKSGGNKKNDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEA
ISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIH
LMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM16426
n/a
NameBDBM16426
Synonyms:2-(2-hydroxyphenyl)acetic acid | 2-Hydroxyphenylacetic acid | Benzeneacetic acid | CHEMBL240714
TypeSmall organic molecule
Emp. Form.C8H8O3
Mol. Mass.152.1473
SMILESOC(=O)Cc1ccccc1O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: