| Reaction Details |
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 | Report a problem with these data |
| Target | Melanoma-associated antigen 4 |
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| Ligand | BDBM50605670 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2252629 (CHEMBL5166839) |
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| IC50 | 14±n/a nM |
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| Citation |  Fleming, MC; Chiou, LF; Tumbale, PP; Droby, GN; Lim, J; Norris-Drouin, JL; Williams, JG; Pearce, KH; Williams, RS; Vaziri, C; Bowers, AA Discovery and Structural Basis of the Selectivity of Potent Cyclic Peptide Inhibitors of MAGE-A4. J Med Chem65:7231-7245 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanoma-associated antigen 4 |
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| Name: | Melanoma-associated antigen 4 |
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| Synonyms: | CT1.4 | Cancer/testis antigen 1.4 | MAGA4_HUMAN | MAGE-4 antigen | MAGE-41 antigen | MAGE-X2 antigen | MAGE4 | MAGEA4 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 34879.63 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_118267 |
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| Residue: | 317 |
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| Sequence: | MSSEQKSQHCKPEEGVEAQEEALGLVGAQAPTTEEQEAAVSSSSPLVPGTLEEVPAAESA
GPPQSPQGASALPTTISFTCWRQPNEGSSSQEEEGPSTSPDAESLFREALSNKVDELAHF
LLRKYRAKELVTKAEMLERVIKNYKRCFPVIFGKASESLKMIFGIDVKEVDPASNTYTLV
TCLGLSYDGLLGNNQIFPKTGLLIIVLGTIAMEGDSASEEEIWEELGVMGVYDGREHTVY
GEPRKLLTQDWVQENYLEYRQVPGSNPARYEFLWGPRALAETSYVKVLEHVVRVNARVRI
AYPSLREAALLEEEEGV
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| BDBM50605670 |
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| n/a |
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| Name | BDBM50605670 |
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| Synonyms: | CHEMBL5182108 |
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| Type | Small organic molecule |
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| Emp. Form. | C61H85N15O17S |
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| Mol. Mass. | 1332.483 |
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| SMILES | [H][C@]1(NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC1=O)C(N)=O)[C@@H](C)CC |r| |
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| Structure | 
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