| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1 |
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| Ligand | BDBM50569838 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2260048 (CHEMBL5215059) |
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| IC50 | 10.0±n/a nM |
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| Citation |  Bass, AKA; El-Zoghbi, MS; Nageeb, EM; Mohamed, MFA; Badr, M; Abuo-Rahma, GEA Comprehensive review for anticancer hybridized multitargeting HDAC inhibitors. Eur J Med Chem209:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 1 |
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| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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| BDBM50569838 |
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| n/a |
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| Name | BDBM50569838 |
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| Synonyms: | EDO-S 101 | EDO-S-101 | EDO-S101 | Tinostamustine |
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| Type | Small organic molecule |
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| Emp. Form. | C19H28Cl2N4O2 |
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| Mol. Mass. | 415.357 |
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| SMILES | Cn1c(CCCCCCC(=O)NO)nc2cc(ccc12)N(CCCl)CCCl |
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| Structure | 
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