| Reaction Details |
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 | Report a problem with these data |
| Target | Protein-S-isoprenylcysteine O-methyltransferase |
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| Ligand | BDBM50189239 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_380404 (CHEMBL864903) |
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| IC50 | 14300±n/a nM |
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| Citation |  Donelson, JL; Hodges, HB; Macdougall, DD; Henriksen, BS; Hrycyna, CA; Gibbs, RA Amide-substituted farnesylcysteine analogs as inhibitors of human isoprenylcysteine carboxyl methyltransferase. Bioorg Med Chem Lett16:4420-3 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein-S-isoprenylcysteine O-methyltransferase |
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| Name: | Protein-S-isoprenylcysteine O-methyltransferase |
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| Synonyms: | ICMT | ICMT_HUMAN | Isoprenylcysteine carboxyl methyltransferase | PCCMT |
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| Type: | PROTEIN |
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| Mol. Mass.: | 31943.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_956034 |
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| Residue: | 284 |
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| Sequence: | MAGCAARAPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYR
PPRYQIAIRACFLGFVFGCGTLLSFSQSSWSHFGWYMCSLSLFHYSEYLVTAVNNPKSLS
LDSFLLNHSLEYTVAALSSWLEFTLENIFWPELKQITWLSVTGLLMVVFGECLRKAAMFT
AGSNFNHVVQNEKSDTHTLVTSGVYAWFRHPSYVGWFYWSIGTQVMLCNPICGVSYALTV
WRFFRDRTEEEEISLIHFFGEEYLEYKKRVPTGLPFIKGVKVDL
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| BDBM50189239 |
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| n/a |
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| Name | BDBM50189239 |
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| Synonyms: | (R)-2-(3,5-dinitrobenzamido)-3-(3,7,11-trimethyldodeca-2,6,10-trienylthio)propanoic acid | CHEMBL212599 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H33N3O7S |
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| Mol. Mass. | 519.61 |
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| SMILES | [#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#16]-[#6]-[#6@H](-[#7]-[#6](=O)-c1cc(cc(c1)-[#7+](-[#8-])=O)-[#7+](-[#8-])=O)-[#6](-[#8])=O |
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| Structure | 
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