| Reaction Details |
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 | Report a problem with these data |
| Target | Transmembrane protease serine 2 |
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| Ligand | BDBM50606674 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2261069 (CHEMBL5216080) |
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| Ki | 3.0±n/a nM |
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| Citation |  Paulsson-Habegger, L; Snabaitis, AK; Wren, SP Enzyme inhibition as a potential therapeutic strategy to treat COVID-19 infection. Bioorg Med Chem48:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transmembrane protease serine 2 |
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| Name: | Transmembrane protease serine 2 |
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| Synonyms: | PRSS10 | Serine protease 10 | TMPRSS2 | TMPS2_HUMAN | Transmembrane protease serine 2 catalytic chain | Transmembrane protease serine 2 non-catalytic chain |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53867.70 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_760112 |
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| Residue: | 492 |
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| Sequence: | MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQA
SNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIEC
DSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENY
GRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLR
CIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEK
PLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDL
VKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLI
TPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVF
TDWIYRQMRADG
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| BDBM50606674 |
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| n/a |
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| Name | BDBM50606674 |
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| Synonyms: | CHEMBL3219103 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H40Cl2N6O4S |
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| Mol. Mass. | 699.69 |
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| SMILES | NC(=N)c1cccc(C[C@H](NS(=O)(=O)c2cccc(c2)-c2ccc(Cl)cc2Cl)C(=O)N2CCC(CC2)NC(=O)NC2CCCCC2)c1 |r| |
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| Structure | 
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