| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Calpain-2 catalytic subunit |
|---|
| Ligand | BDBM50189829 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_367108 (CHEMBL863672) |
|---|
| IC50 | 1900±n/a nM |
|---|
| Citation |  Shirasaki, Y; Nakamura, M; Yamaguchi, M; Miyashita, H; Sakai, O; Inoue, J Exploration of orally available calpain inhibitors 2: peptidyl hemiacetal derivatives. J Med Chem49:3926-32 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Calpain-2 catalytic subunit |
|---|
| Name: | Calpain-2 catalytic subunit |
|---|
| Synonyms: | 3.4.22.53 | CAN2_PIG | CANP 2 | CAPN2 | Calcium-activated neutral proteinase 2 | Calpain 2 | Calpain M-type | Calpain-2 catalytic subunit | Calpain-2 large subunit | M-calpain | Millimolar-calpain |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 37789.71 |
|---|
| Organism: | Sus scrofa |
|---|
| Description: | n/a |
|---|
| Residue: | 324 |
|---|
| Sequence: | YPNTFWMNPQYLIKLEEEDEDQEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEV
PEELTGQTNIHLSKNFFLTHRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGD
FCIRVFSEKKADYQVVDDEIEADLEENDASEDDIDDGFRRLFAQLAGEDAEISAFELQTI
LRRVLAKRQDIKSDGFSIETCRIMVDMLDSDGSAKLGLKEFYILWTKIQKYQKIYREIDV
DRSGTMNSYEMRKALEEAGFKLPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFRIS
KQLDSENTGTIELDLISWLCFSVL
|
|
|
|---|
| BDBM50189829 |
|---|
| n/a |
|---|
| Name | BDBM50189829 |
|---|
| Synonyms: | (2S)-3-methyl-2-(((phenylamino)thioxomethyl)amino)-N-((3S)-tetrahydro-2-hydroxy-3-furanyl)butanamide | CHEMBL377197 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H23N3O3S |
|---|
| Mol. Mass. | 337.437 |
|---|
| SMILES | CC(C)[C@H](NC(=S)Nc1ccccc1)C(=O)N[C@H]1CCOC1O |
|---|
| Structure | 
|
|---|
Search and Browse
