| Reaction Details |
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 | Report a problem with these data |
| Target | Calpain-1 catalytic subunit |
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| Ligand | BDBM50114342 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_367107 (CHEMBL863671) |
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| IC50 | 370±n/a nM |
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| Citation |  Shirasaki, Y; Nakamura, M; Yamaguchi, M; Miyashita, H; Sakai, O; Inoue, J Exploration of orally available calpain inhibitors 2: peptidyl hemiacetal derivatives. J Med Chem49:3926-32 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Calpain-1 catalytic subunit |
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| Name: | Calpain-1 catalytic subunit |
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| Synonyms: | CAN1_HUMAN | CANPL1 | CAPN1 | Calpain ยต-type | Calpain-1 (u-Calpain) | Calpain-1 catalytic subunit | Calpain1 |
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| Type: | Protein |
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| Mol. Mass.: | 81880.51 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 714 |
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| Sequence: | MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEA
FPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAA
IASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHS
AEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILK
ALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGE
VEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKS
RTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFV
LALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINL
REVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSE
EEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRD
GNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELII
TRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA
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| BDBM50114342 |
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| n/a |
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| Name | BDBM50114342 |
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| Synonyms: | (E)-2-(dimethylamino)-N'-((S)-2-((S)-2-(4-fluorophenylsulfonamido)-3-methylbutanamido)-4-methylpentylidene)acetohydrazide | (S)-N-{(S)-1-[(2-Dimethylamino-acetyl)-hydrazonomethyl]-3-methyl-butyl}-2-(4-fluoro-benzenesulfonylamino)-3-methyl-butyramide | CHEMBL288882 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H34FN5O4S |
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| Mol. Mass. | 471.589 |
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| SMILES | CC(C)C[C@H](NC(=O)[C@@H](NS(=O)(=O)c1ccc(F)cc1)C(C)C)C=NNC(=O)CN(C)C |w:24.25| |
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| Structure | 
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